150 Years of the Paraskeva Nikolau Donation Hospital, Varna

The history of the city of Varna, like the history of each city, is rich in events, many of which have disappeared or are forgotten, but others have not disappeared and are not forgotten and have become symbols of the city not only in the past but also today and in the future!In the rich history of Varna, there are many such symbols that exist until today

Epidemics In The North Bulgarian Black Sea Region In XIX Century. 1. Contributions of assoc. Prof. Vladimir vassilev, MD, PHD, DMS For Their Study

Епидемиите от заразни болести възникват много често изненадващо и много бързо засягат населението на обширни територии, прераствайки в пандемии. През XIX век областта на северното Българско Черноморие е арена на няколко военни конфликта, всеки един от които се придружава от различни епидемии. В настоящата статия се дискутират приносите на моя колега, забележителния български учен в областта на историята на медицината, ст.н.с. д-р Владимир Добринов Василев, д.м.н., за детайлните и много компетентни изследвания на споменатите по-горе епидемии, на базата на неговия много богат личен архив, както и на базата на моите лични контакти с него по проблема „История на медицината”.The epidemics of contagious diseases arise very often surprisingly, and very quickly affect the people from large territories, increasing in pandemics. During the XIX century, the North Bulgaria Black Sea region was arena of several military conflicts, every one of which was accompanied from various epidemics. In this paper are discussed the contributions of my college, famous Bulgarian scientist in the field of History of Medicine, Assoc. Prof. Vladimir Dobrinov Vassilev, MD, PhD, DMS, for detailed and very competent studies of the epidemics mentioned above, on the basis of her very rich personal archive, as well as on the basis of my personal communications with him on the topics „History of Medicine”

Rare Anatomic Variations of the Female Reproductive System Published in Bulgarian Medical Literature in Late XIX. Century

Periodic medical press in Bulgaria dates back to 80s of the XIX century, when the first scientific medical journals have been published. A sample of publications devoted to a specific medical problem, i. e. of the rare variations of the female reproductive system was studied by means of a detailed analysis of the literature from this period. In this paper the articles concerning the description of variations, journals containing them and their authors along with a short biographic data were presented. The results showed a high professionalism and desire for research of these authors

DEVELOPING LOW-CARBON TOURISM IN PUGLIA: CASE STUDY OF I. ARCHEO.S PROJECT

This paper aims to examine the main determinants for developing low carbon tourism in Puglia region, studying the perceptions of a focus group of ca. 60 public and private stakeholders within Interreg project Italy-Croatia named I.-Archeo.S. project; Data were collected during I-Archeo.S itinerary (N=40) and through personal interviews (N=10) in March 2019. Statistical modelling of t-test, varimax rotation as well as Likert- scale was applied to study the factors of influence for tourist behavior and sustainable tourism (i.e. availability of ecological certification, participation in eco-initiatives, interest in typical products, green event awareness etc.). The results reveal that low-carbon travel is becoming the main way to stimulate the development of sustainable tourism in Puglia region. The increasing necessity for ecological knowledge and cultural heritage protection are perceived as significant factors for low-carbon tourism performance. These findings can help stakeholders from tourism and cultural sectors in Puglia region to prioritise resources and services across different seasons. Although the literature identifies dimensions of sustainable tourism, case studies on low-carbon tourism are still sparse. This study, therefore, contributes to expanding this body of knowledge

Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease

We agree with Brunet and Doolittle (1) on the utility of distinguishing the evolutionarily selected effects (SE) of some genomic elements from the causal roles (CR) of other elements that lack signatures of selection (1⇓⇓–4). DNA sequences identified by biochemical approaches include both SE and CR elements, and genetic variation in both has been implicated in human traits and disease susceptibility. We thus view the Encyclopedia of DNA Elements (ENCODE) catalog and similar data resources as important foundations for understanding the DNA elements and molecular mechanisms underlying human biology and disease

Defining functional DNA elements in the human genome

With the completion of the human genome sequence, attention turned to identifying and annotating its functional DNA elements. As a complement to genetic and comparative genomics approaches, the Encyclopedia of DNA Elements Project was launched to contribute maps of RNA transcripts, transcriptional regulator binding sites, and chromatin states in many cell types. The resulting genome-wide data reveal sites of biochemical activity with high positional resolution and cell type specificity that facilitate studies of gene regulation and interpretation of noncoding variants associated with human disease. However, the biochemically active regions cover a much larger fraction of the genome than do evolutionarily conserved regions, raising the question of whether nonconserved but biochemically active regions are truly functional. Here, we review the strengths and limitations of biochemical, evolutionary, and genetic approaches for defining functional DNA segments, potential sources for the observed differences in estimated genomic coverage, and the biological implications of these discrepancies. We also analyze the relationship between signal intensity, genomic coverage, and evolutionary conservation. Our results reinforce the principle that each approach provides complementary information and that we need to use combinations of all three to elucidate genome function in human biology and disease

CALCULATION OF LOSSES OF ACTIVE POWER AND ENERGY IN TRANSMISSION LINES AND TRANSFORMERS, AS A PART OF THE ELECTRICAL DISTRIBUTION POWER NETWORK

The paper inhere discusses the impact of renewable distributed generation sources upon the power and energy losses in electrical distribution power networks where these sources are attached. In addition a set of mathematical expressions to calculate these active power and energy losses are presented with the respective examples and implementation

Mercury self-poisoning. Case report

A clinical case of a self-poisoning with a single ingestion of 40-45 mL of alleged metal mercury with suicid­al purpose by a 50-year-old man is described. On the following day he was admitted to the Toxicology Clinic with symptoms of nausea, strong abdominal colic, diarrhea, and feces with macroscopic admixture of mer­cury drops. At the inspection of the residue of the substance, an unusual black-grey color on its surface was noted. Later, mercurous oxide was proven by chemical analysis. No toxic symptoms of the central nervous system, respiratory system or kidneys were observed. X-rays of the abdomen were performed and tracked dynamically: the first one showed numerous round shadows with metal density along the whole colon, the second - after 5 days - showed reduced number of similar shadows only in the distant colon, and the third X-ray on the 9th day was normal. Mercury was discovered in the blood: 0.250 μmol L-1 on the fourth day after the ingestion and 0.120 μmol L-1 - on the tenth day. Some therapeutic problems of acute mercury intoxica­tion of present interest are discussed

Rapid toxicochemical analysis in phosphide intoxication cases

In recent years, phosphine and metal phosphides intoxications have been observed extremely rarely in clinical practice. Although rare, these intoxications have a severe clinical course, often with unclear clinical presentation at the beginning and possible lethal exit during the first hours or the next several days. Several tests for analysis of phosphide intoxication, based on the classical qualitative semimicroanalysis which do not require complex equipment, are presented and compared in this article. These tests contribute significantly to confirming the toxicology diagnosis and identifying the source. A rapid paper test (adopting the method of Chugh et al.) has been developed for the purposes of the routine toxicology practice to serve the practicing doctor, as quick and exact diagnostic orientation in cases with unclear history and clinical presentation of the intoxication